Matt Hasselbeck, playing his first game since Thanksgiving Day, overcame two interceptions in his first three throws to connect with John Carlson for two touchdowns in the host Seattle Seahawks' 28-0 romp over the St. Louis Rams on Sunday.
Hasselbeck finished 25-of-36 for 279 yards, his most for an opener. Seattle beat its division rival for the ninth consecutive time with its biggest win to begin a season since a 38-0 victory over the Philadelphia Eagles in 1998.
The Rams, under new coach Steve Spagnuolo, gained just 247 yards in a flop that looked alarmingly like their 38-3 loss to the Eagles that opened last season.
Packers 21, Bears 15: Aaron Rodgers brought the Packers back late in the fourth quarter, heaving a 50-yard touchdown pass to Greg Jennings with 1:11 remaining to give host Green Bay a victory over Chicago.
Facing third-and-1 at the 50-yard line, Rodgers faked play action and heaved a rainbow of a throw deep to Jennings, who ran in for the go-ahead TD. Rodgers found Jennings again for a 2-point conversion.
Broncos 12, Bengals 7: Brandon Stokley caught a tipped pass and outran host Cincinnati's shocked defenders for an 87-yard touchdown with 11 seconds left to help Denver to a 12-7 win.
After Cedric Benson's 1-yard run put Cincinnati ahead 7-6 with 38 seconds left, Kyle Orton -- in line to shoulder the blame for a Denver loss -- threw a desperate pass into a crowd at the sideline, hoping Brandon Marshall would somehow come down with it.
Marshall never got close. Cornerback Leon Hall batted the ball in the air, and the carom went right into the arms of Stokley, who was behind the defense and had a clear path to the end zone.
Hill directed a 15-play, 80-yard drive for the winning touchdown on a 3-yard pass to Frank Gore, and the visiting 49ers spoiled the season debut of defending NFC champion Arizona.
Arizona rallied from 10 points down to go up 16-13 on Neil Rackers' 44-yard field goal with 14:52 to play. But the 49ers regained control with the drive that used up nearly half of the final quarter.
It was the Cardinals' first loss to an NFC West foe in two seasons.
Jets 24, Texans 7: As good as Mark Sanchez was in his NFL debut, the Jets' defense was better.
Sanchez, the fifth overall pick in this year's draft, threw for 272 yards and a touchdown in his NFL debut, Thomas Jones scored twice, and the Jets shut down host Houston's high-powered offense.
Houston's offense got past midfield just once in the first three quarters. The Texans were outgained 462-183, Steve Slaton was held to 17 yards rushing and Andre Johnson had 35 yards receiving.
Ravens 38, Chiefs 24: Joe Flacco went 26-of-43 for 307 yards and three touchdowns, all career highs, and host Baltimore ruined the head coaching debut of Kansas City's Todd Haley.
The Ravens amassed a franchise-record 501 yards yet needed a 31-yard touchdown catch by Mark Clayton with 2:06 left to break a tie.
Willis McGahee scored from the 1 with 31 seconds remaining to clinch it.
Cowboys 34, Buccaneers 21: Tony Romo threw for 353 yards and three long touchdowns, spoiling host Tampa Bay's debut under coach Raheem Morris.
Romo teamed with Patrick Crayton, who had six catches for 135 yards, on the longest completion of the Pro Bowl quarterback's career -- 80 yards -- for a fourth-quarter TD that thwarted any realistic hopes for a Tampa Bay comeback.
Falcons 19, Dolphins 7: Tony Gonzalez hauled in a touchdown pass and became the 21st player in NFL history with 11,000 yards receiving. Linebacker Mike Peterson forced a fumble with a vicious hit and picked off a pass for the host Falcons.
Matt Ryan threw two touchdown passes, and Gonzalez hauled in five passes for a team-high 73 yards, including a 20-yard touchdown after Peterson's pick.
Colts 14, Jaguars 12: Peyton Manning threw for one touchdown, Joseph Addai ran for another and Indianapolis' defense stopped visiting Jacksonville twice in the fourth quarter.
Though Manning tied Johnny Unitas' franchise record for career wins with 118, it was hardly a thing of beauty. Manning lost receiver Anthony Gonzalez late in the first quarter with a right knee injury, a potentially serious blow to the Colts' usually high-scoring offense. Reggie Wayne finished with 10 catches for 162 yards and a TD, and Colts coach Jim Caldwell won his NFL head coaching debut.