Tre Frederick rushed for three touchdowns while Cameron Williams passed for two and ran for another as West Johnston walloped county rival Smithfield-Selma 39-6 Friday night.
It was the fifth straight win in the series for the 4A Wildcats, who went 4-7 last season.
SSS, which dressed 20 players for the opener, beat 3A rival South Johnston in its season finale last year to end a 40-game losing streak.
"We held them to 17 yards in the first half and that was really good," West coach Jimmy Williams said. "I think we got a little complacent later in the game, and our offensive line still needs work. But overall it was a good start to the season."
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Quarterback Austin Blackmon scored the Spartans' touchdown in the fourth quarter.
Williams completed six of 12 passes for 158 yards and rushed three times for 16 for West, while Frederick rushed 14 times for 61 yards while catching two passes for 18 more.
The Wildcats dominated thoroughly from the outset.
West led 27-0 at the half, courtesy of one big offensive play and three SSS mistakes deep in Spartans territory.
The Wildcats scored on their first three possessions, the first a four-play, 69-yard drive including a 68-yard pass from Williams to Brandon Baucom. Frederick bulled in from a yard out.
After a Spartan fake punt went awry, the Wildcats took over at the 14 needed just two plays to score with Williams connecting to Josh Collier on a tipped ball from nine yards out.
West made it 21-0 with 5:28 left in the first, following Collier's interception of a Blackmon pass at the Spartan 29. Williams scrambled in from 11 yards out for the TD.
Frederick again went in from a yard out with 5:56 left in the second to make it 27-0.
West made it 33-0 on Williams' eight-yard pass to Cameron Hairston to finish a seven-play, 73-yard drive with 9:24 left in the third.
And Frederick scored on a 20-yard burst with 7:49 remaining in the third to make it 39-0.
SSS broke the shutout with 6:15 left in the game as Blackmon scored on a keeper from four yards out.
Tyler McDougall led SSS with 60 yards on seven carries.
West will travel to South Johnston next Friday night, while Smithfield-Selma will host its home opener against Southern Wayne.