Fire early Tuesday damaged a three-story building at 118 W. Parrish St., an area known historically as the "Black Wall Street" for its role in financial affairs.
Firefighters found heavy smoke coming from the roof at the back of the 99-year-old building shortly after the fire was reported at 2:05 a.m., Deputy Chief Chris Iannuzzi said.
The same building had a middle-of-the-night fire on May 14, 2014.
After they forced their way into the building, crews got the blaze under control in about 15 minutes, Iannuzzi said.
The third floor, which Iannuzzi said was vacant, suffered fire and smoke damage. The second floor, which the chief said was occupied, and the vacant first floor were damaged by water, he said.
The cause of the fire was under investigation.
The building was built in 1916, according to tax records, and is classified as a retail building.
Durham-based Eno Ventures bought the building for $1 million in 2012, records showed.