Three of Interstate 85's five northbound lanes were closed west of Hillsborough on Monday morning by a wreck involving two tractor-trailers, officials said.
The crash was near the 157 mile marker and the Buckhorn Road exit, the state Department of Transportation said.
It happened shortly after 7 a.m.
Orange County EMS took one person to a hospital, officials said, but no details were available.
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Firefighters reported a fuel leak from a truck.
The highway is also Interstate 40, but officials use I-85 mile measurements in that section.