Case Keenum, Houston, threw for 376 yards and tied his career high with six TD passes while becoming the NCAA's all-time leader in total yards in the No. 21 Cougars' 63-28 win over Marshall.
AJ McCarron, Alabama, passed for 284 yards and a touchdown and ran for another score to lead the No. 2 Crimson Tide to a 37-6 rout of Tennessee.
Brady Attaway, Stephen F. Austin, threw for 364 yards and seven TDs in a 57-21 win over Nicholls State.
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Zach Collaros, Cincinnati, threw for three TDs and ran for two fourth-quarter scores in a 37-34 comeback victory over South Florida.
Tajh Boyd, Clemson, threw for 367 yards and tied a school record with five TD passes in a 59-38 victory over North Carolina
Joseph Randle, Oklahoma State, ran for 138 yards and accounted for four TDs as the No. 6 Cowboys remained unbeaten and ended Missouri's 10-game home winning streak with a 45-24 victory.
Dan Di Lella, Albany (N.Y.), threw for 283 yards a school-record five TDs in a 63-35 rout of Central Connecticut State.
Collin Klein, Kansas State, threw for a career-high 195 yards and accounted for five TDs to help the No. 12 Wildcats rout rival Kansas 59-21.
Riley Nelson, BYU, passed for 215 yards and three touchdowns while rushing for 62 yards and another TD in a 56-3 victory over Idaho State.
Collier Winters, Harvard, passed for 403 yards, five touchdowns and rushed for a score in a 56-39 win against rival Princeton.
Cody Fajardo, Nevada, passed for 313 yards and a touchdown and ran for 61 yards and another score in a 45-38 win over Fresno State.
After a heave, a carom, a desperate struggle for the last few inches and a further review, Michigan State pulled off a miraculous win.
Keith Nichol caught a 44-yard pass from Kirk Cousins on the game's final play for a tiebreaking touchdown, giving the 15th-ranked Spartans a 37-31 victory against No. 4 Wisconsin.
With 4 seconds left, Cousins rolled out to his right and threw it about as far as he could. The ball went into the end zone but caromed off Michigan State receiver B.J. Cunningham's facemask back to Nichol, who caught it just outside the end zone and struggled for the goal line, fighting two Wisconsin defenders and just barely breaking the plane.
The former backup quarterback was initially ruled short of the end zone, but officials overturned the call after a review, giving the Spartans (6-1, 3-0 Big Ten) the win and knocking the Badgers (6-1, 2-1) from the ranks of the unbeaten.
Top-ranked LSU didn't seem to mind missing three key players, thanks to Rueben Randle.
Randle caught a 42-yard scoring pass from Jordan Jefferson and a 46-yard touchdown pass from Jarrett Lee, and the Tigers once again overcame off-the-field distractions in style with a 45-10 victory over 19th-ranked Auburn.
LSU was without star cornerback Tyrann Mathieu, leading rusher Spencer Ware and defensive back Tharold Simon -- all suspended one game for violating the team's drug policy.
Yet LSU continued to make team history with its eighth double-digit win in as many games this season, a streak that started with a season-opening triumph over Oregon without the then-suspended Jefferson and receiver Russell Shepard.
Off next week, LSU (8-0, 5-0 SEC) will be unbeaten entering its showdown at No. 2 Alabama on Nov. 5.
JOEPA MATCHES ROBINSON
Penn State coach Joe Paterno tied Eddie Robinson's Division I record with his 408th career victory with the Nittany Lions' 34-24 win over Northwestern 34-24.
Coaching again from a box upstairs, watched as Silas Redd ran for 164 yards and a touchdown, Matt McGloin threw for 192 yards and two scores, and the Nittany Lions clamped down in the second half to give their storied coach another milestone victory.
Paterno will try to move ahead of Robinson, the Grambling State legend, when the Nittany Lions (7-1, 4-0 Big Ten) host Illinois next Saturday. That starts a tough stretch that also includes a home game against Nebraska before trips to Ohio State and Wisconsin.
Paterno still has a long way to go to catch John Gagliardi of Division III St. John's, Minn. (481 and counting), the only other coach with more wins, but this was another big notch for an icon in his 46th season leading the Nittany Lions.
East Carolina's Dominique Davis, Boise State's Kellen Moore and Houston's Case Keenum all put their names in the NCAA record book.
Davis broke two for successive completions -- single game and in two games -- Keenum set the NCAA's career total offense mark and Moore matched the all-time wins mark.
Davis completed his first 26 passes against Navy on Saturday, breaking the single-game record of 23 set by Tee Martin of Tennessee in 1998 and tied by Aaron Rodgers of California in 2004.
Davis went 26 for 26 for 251 yards in the first half against Navy. The senior completed his final 10 passes last week against Memphis, giving him 36 straight completed passes -- eclipsing the season mark of 26 set by Rodgers in 2004.
Keenum, a senior granted a sixth season after a knee injury last year, came into the game needing 130 yards to eclipse the record (16,910 yards) set by Hawaii's Tim Chang from 2000-04. He moved past Chang's mark on a 30-yard pass to Justin Johnson with 3:56 left in the quarter.
Keenum and the Cougars won 63-28 and he threw for 376 yards and six touchdowns. He completed 24 of 28 passes -- 15 in a row during one stretch -- and also crept closer to the FBS career records for passing yards and touchdown throws. He needs 802 passing yards to move ahead of Chang's record (17,072) and five TD passes to eclipse the high mark (134) set by Texas Tech's Graham Harrell from 2005-08.
Moore tied Texas' Colt McCoy for most wins all-time with 45 after the No. 6 Broncos beat Air Force 33-26. He also three three TD passes to move into fourth all-time with 123 for his career ahead of past former BYU quarterback Ty Detmer.
10: Straight losses by Mississippi in the SEC, its longest as a program, after No. 10 Arkansas rallied for a 29-24 win.
16: Straight victories in the Pioneer Football League -- a record -- by Jacksonville after its win Davidson.
18: Games in the home losing streak ended by Western Kentucky with its 42-23 win over Louisiana-Lafayette.
23: Points in the fourth quarter by Maine in its 23-22 win over Richmond 23-22.
24: Career touchdown receptions by Iowa's Marvin McNutt, breaking the mark held by Tim Dwight and Danan Hughes at 21.
69: Points by TCU in its shutout win over New Mexico, breaking the school record of 68 against Austin College in 1932.
83: Points scored by Johns Hopkins in a win over Gettysburg.
446: Yards rushing by No. 7 Stanford in a 65-21 win over No. 22 Washington, breaking the school record of 439 in a victory over Oregon State in 1981.