A man and a woman were found shot on East Jones Street, northeast of downtown, on Tuesday night, police said.
Both were seriously hurt, police said in a statement. It said the man was 48 years old and the woman was 29.
Officers found the two in the 1500 block after being sent to a call about shots being fired.
The block is between St. Augustine Avenue and Hill Street, three blocks south of Saint Augustine's University.
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Police did not disclose any information about where in the block the two were found of it either or both lived in the area.