Police are trying to find a vehicle that hit a pedestrian at Fordham Boulevard and East Lakeview Drive early Monday morning and drove off.
Police were dispatched to the scene at 3:37 a.m., a spokesman said.
Joseph Russo, 23, of Durham, was taken to Duke University Hospital, where he is listed in critical condition, police said.
Police asked anyone with information that might help investigators to call the Chapel Hill Police Department at 919-968-2760.
The accident scene is about 1,000 feet southwest of the Interstate 40 interchange with Fordham Boulevard, which is U.S. 15-501.