Police closed southbound Capital Boulevard between Hodges Street and Crabtree Boulevard, just south of the I-440 Beltline, so crews could find and repair a broken water main.
The break was discovered in mid-morning, and police stationed officers to divert vehicles off the artery.
Police said Public Utilities Department workers were trying to pinpoint the break so they could begin digging to fix the pipe.
Police also asked state officials to keep drivers from exiting Interstate 440 onto southbound Capital Boulevard to reduce traffic at the closure.
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