Six schools from North Carolina made the NCAA tournament this year. But the teams haven't had much success so far during the first round.
After Friday's games, North Carolina schools are 2-4.
No. 2 seed Duke (27-7) pulled away in the second half and blew out No. 15 seed Iona in the Midwest Region in Pittsburgh.
No. 9 seed N.C. State (21-12) fell behind No. 8 seed Seton Hall early and was never able to regain the lead in losing 94-83 in the Midwest Region in Wichita, Kansas.
No. 13 seed UNC Greensboro almost pulled off the biggest upset of the first day, falling 68-64 to No. 4 seed Gonzaga. The Spartans (27-8) had a late lead, but the Zags rallied.
N.C. Central (19-16) lost 64-46 to Texas Southern in Wednesday's play-in game.
No. 12 seed Davidson (21-12) finished the day by falling to Kentucky 78-73 in Boise, Idaho.
No. 2 seed North Carolina (26-10) struggled early but eventuall rolled past No. 15 seed Lipscomb 84-66 on Friday in Charlotte.
No. 6 seed Miami was upset by No. 11 seed Loyola (Chicago), and No. 8 seed Virginia Tech fell 86-83 to No. 9 seed Alabama on Thursday.
Virginia, Syracuse and Florida State play later on Friday.
The ACC is 3-3 in the tournament.